BAKER BROS. ADVISORS LP
Institutional investor · Portfolio as of Q4 2025
Top Holdings86 positions
INCYTE CORP | 30.7M | $3B | 17.8% | $84.99 | +16.22% | 28 qtrssince 2019-Q1 | Increased 62 |
BEIGENE LTD | 8.8M | $2.7B | 15.7% | $149.70 | +102.95% | 28 qtrssince 2019-Q1 | Unchanged 0 |
MADRIGAL PHARMACEUTICALS INC COM | 2.1M | $1.2B | 7.3% | $167.08 | +248.53% | 28 qtrssince 2019-Q1 | Unchanged 0 |
INSMED INC | 6.6M | $1.1B | 6.7% | $76.23 | +128.30% | 28 qtrssince 2019-Q1 | Decreased 0 |
ACADIA PHARMACEUTICALS INC | 42.9M | $1.1B | 6.7% | $27.48 | -2.82% | 28 qtrssince 2019-Q1 | Unchanged 0 |
CELCUITY INC COM | 7.9M | $789.5M | 4.6% | $25.54 | +291.18% | 10 qtrssince 2023-Q3 | Unchanged 0 |
REVOLUTION MEDICINES INC COM | 9.5M | $753.1M | 4.4% | $30.05 | +165.14% | 20 qtrssince 2021-Q1 | Unchanged 0 |
KYMERA THERAPEUTICS INC COM | 8.7M | $673.6M | 3.9% | $40.89 | +90.27% | 22 qtrssince 2020-Q3 | Increased 73 |
SUMMIT THERAPEUTICS INC COM | 36.4M | $636.5M | 3.7% | $12.21 | +43.20% | 7 qtrssince 2024-Q2 | Increased 63 |
RHYTHM PHARMACEUTICALS INC | 5.6M | $599.9M | 3.5% | $24.17 | +342.94% | 28 qtrssince 2019-Q1 | Unchanged 0 |
KODIAK SCIENCES INC COM | 19.9M | $556.9M | 3.3% | $33.21 | -15.81% | 28 qtrssince 2019-Q1 | Increased 66 |
PRAXIS PRECISION MEDICINES INC COM NEW | 1.1M | $332M | 1.9% | $145.19 | +103.01% | 8 qtrssince 2024-Q1 | Increased 71 |
ALKERMES PLC | 10M | $280.1M | 1.6% | $26.97 | +3.74% | 7 qtrssince 2024-Q2 | Increased 59 |
GRAIL INC COM | 2.1M | $178.5M | 1.0% | $33.19 | +157.00% | 5 qtrssince 2024-Q4 | Increased 60 |
EDGEWISE THERAPEUTICS INC COM | 6.6M | $163.2M | 1.0% | $15.71 | +56.22% | 20 qtrssince 2021-Q1 | Decreased 0 |
ARROWHEAD PHARMACEUTICALS IN | 2.2M | $144.4M | 0.8% | $33.82 | +96.28% | 3 qtrssince 2025-Q2 | Increased 54 |
IONIS PHARMACEUTICALS INC | 1.8M | $141.8M | 0.8% | $74.78 | +5.79% | 2 qtrssince 2025-Q3 | Increased 69 |
IMMUNOVANT INC COM | 5.5M | $138.7M | 0.8% | $21.82 | +16.18% | 10 qtrssince 2023-Q3 | Unchanged 0 |
IMMATICS N.V SHS | 12.1M | $127M | 0.7% | $8.87 | +13.56% | 22 qtrssince 2020-Q3 | Unchanged 0 |
IDEAYA Biosciences Inc. | 3.6M | $125.1M | 0.7% | $22.92 | +50.54% | 14 qtrssince 2022-Q3 | Increased 47 |
BAKER BROS. ADVISORS LP manages $17.1B across 86 positions as of Q4 2025. Top holdings: INCY (17.8%), ONC (15.7%), MDGL (7.3%). Fund DNA: Concentrated Value. HoldingsIntel Score: 3/5.0.
Active quarter - 9 new positions, 14 exits, 23 increased. Top move: KYMR (INCREASED, conviction 73). Portfolio: $17.1B across 86 positions.
Top holdings by portfolio weight
Portfolio allocation by GICS sector
Behavioral investing profile
Position Outcomes
Best and worst performing positions by estimated return
Top Winners
Top Losers
Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.
Similar Funds
Funds with similar investing DNA
Explore More
Accumulation Streaks
Positions with 2+ consecutive quarters of increases - persistent directional conviction.
Continue exploring
Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer
Verify source filings on SEC EDGAR