BAKER BROS. ADVISORS LPBAKER BROS. ADVISORS LP

Institutional investor · Portfolio as of Q1 2019

SEC EDGAR SourceSEC Filings

Top Holdings96 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction
51M$3.7B23.9%
1 qtr
New
98

INCYTE CORP

34.3M$2.9B18.9%$86.010.00%
1 qtr
New
98
ONCONC
ADR

BEIGENE LTD-ADR

12M$1.6B10.1%$132.000.00%
1 qtr
New
98
ALXNALXNDelisted

ALEXION PHARMACEUTICALS INC

8.6M$1.2B7.4%
1 qtr
New
98

ACADIA Pharmaceuticals Inc.

39.7M$1.1B6.8%$26.850.00%
1 qtr
New
98
AMRNAMRN
ADR

Amarin Corporation plc

43.2M$897M5.7%
GHDXGHDXDelisted

GENOMIC HEALTH INC

10.2M$714.4M4.6%
1 qtr
New
88

BIOMARIN PHARMACEUTICAL INC

7.6M$674.2M4.3%$88.830.00%
1 qtr
New
87
ASNDASND
ADR

ASCENDIS PHARMA A/S

3.4M$399M2.6%$117.700.00%
1 qtr
New
81
MRTXMRTXDelisted

MIRATI THERAPEUTICS INC

2.5M$184.2M1.2%
1 qtr
New
70

MADRIGAL PHARMACEUTICALS INC

1.2M$146.5M0.9%$125.260.00%
1 qtr
New
59
ARGXARGX
ADR

ARGENX SE - ADR

1M$127.3M0.8%$124.840.00%
1 qtr
New
59

BIOCRYST PHARMACEUTICALS INC

15.1M$123.1M0.8%$8.140.00%
1 qtr
New
59

HERON THERAPEUTICS INC

5M$122.6M0.8%$24.440.00%
1 qtr
New
59
CMCMTADelisted

Clementia Pharmaceuticals Inc.

3.7M$97.2M0.6%
1 qtr
New
58

NEUROCRINE BIOSCIENCES INC

1.1M$96.8M0.6%$88.100.00%
1 qtr
New
58
3.8M$93.7M0.6%
1 qtr
New
58
NVTAQNVTAQDelisted

INVITAE CORP

3.9M$91.4M0.6%
1 qtr
New
58
ONCEONCEDelisted

SPARK THERAPEUTICS INC

751,927$85.6M0.5%
1 qtr
New
58
CBAYCBAYDelisted

CYMABAY THERAPEUTICS INC

5.7M$75.8M0.5%
1 qtr
New
49
$15.6B
AUM
96
Positions
Q1 2019
Filing
Rating · 3.5
Quarterly Portfolio Change
Not enough history yet
Activity profile
$ moved · Q1'19
New100%Increased0%Decreased0%Exited0%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.0 quarters
<1Q89%1-4Q0%1-2Y0%2Y+11%

BAKER BROS. ADVISORS LP manages $15.6B across 96 positions as of Q1 2019. Top holdings: SGEN (23.9%), INCY (18.9%), ONC (10.1%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3.5/5.0.

Q1 2019 Summary

Active quarter - 96 new positions, 0 exits, 0 increased. Top move: SGEN (NEW, conviction 98). Portfolio: $15.6B across 96 positions.

Top holdings by portfolio weight

Total AUM$16B
SGEN23.93%
INCY18.87%
ONC10.11%
ALXN7.41%
ACAD6.83%
AMRN5.74%
GHDX4.57%
BMRN4.32%
ASND2.55%
MRTX1.18%
Other0.94%

Portfolio allocation by GICS sector

Sectors2
Healthcare57.19%
Unknown42.81%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension quality assessment
Strong(3.5 / 5.0)
Track Record66
Conviction39
Concentration100
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Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
8Q
INCYINCYINCYTE CORP
Q3 2024 Q2 2026+23,806 shares+$1.6B
5Q
IDYAIDYAIDEAYA BIOSCIENCES INC
Q2 2025 Q2 2026+3.9M shares+$169.3M
3Q
DSGNDSGNDESIGN THERAPEUTICS INC
Q4 2025 Q2 2026+965,548 shares+$25.9M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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