BAKER BROS. ADVISORS LPBAKER BROS. ADVISORS LP

Institutional investor · Portfolio as of Q2 2021

Top Holdings120 positions

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Activity:
SGENSGENDelisted

SEAGEN INC

47.3M$7.5B32.8%——
4 qtrssince 2020-Q3
Increased
62
ONCONC
ADR

BEONE MEDICINES LTD

11.7M$4B17.6%$149.13+139.45%
10 qtrssince 2019-Q1
Unchanged
0

INCYTE CORP

32M$2.7B11.8%$86.02-2.20%
10 qtrssince 2019-Q1
Increased
62

KODIAK SCIENCES INC

14.1M$1.3B5.8%$36.51+154.71%
10 qtrssince 2019-Q1
Increased
63

ACADIA PHARMACEUTICALS INC

41.9M$1B4.5%$27.58-11.55%
10 qtrssince 2019-Q1
Unchanged
0

BIOMARIN PHARMACEUTICAL INC

7.6M$633.3M2.8%$88.83-6.05%
10 qtrssince 2019-Q1
Unchanged
0
ASNDASND
ADR

ASCENDIS PHARMA A/S

3.5M$465.7M2.0%$119.16+12.68%
10 qtrssince 2019-Q1
Unchanged
0
NVTAQNVTAQDelisted

INVITAE CORP

10.2M$345.7M1.5%——
10 qtrssince 2019-Q1
Decreased
0
ARGXARGX
ADR

ARGENX SE

1.1M$337.1M1.5%$138.29+117.71%
10 qtrssince 2019-Q1
Unchanged
0

PRELUDE THERAPEUTICS INC

10.1M$289.8M1.3%$28.85+4.07%
4 qtrssince 2020-Q3
Unchanged
0
IGMSIGMSDelisted

IGM BIOSCIENCES INC

3.2M$262.6M1.2%——
8 qtrssince 2019-Q3
Unchanged
0

ABCELLERA BIOLOGICS INC

10.5M$229.9M1.0%$41.10-48.22%
3 qtrssince 2020-Q4
Unchanged
0
MRTXMRTXDelisted

MIRATI THERAPEUTICS INC

1.4M$227.7M1.0%——
10 qtrssince 2019-Q1
Unchanged
0

BIOCRYST PHARMACEUTICALS INC

12.7M$201M0.9%$7.50+106.66%
10 qtrssince 2019-Q1
Unchanged
0

MADRIGAL PHARMACEUTICALS INC

1.5M$146M0.6%$112.39-13.33%
10 qtrssince 2019-Q1
Unchanged
0
APLSAPLSDelisted

APELLIS PHARMACEUTICALS INC

2.3M$143.6M0.6%$41.21-0.42%
10 qtrssince 2019-Q1
Increased
55

HERON THERAPEUTICS INC

8.1M$126.2M0.6%$21.40-27.07%
10 qtrssince 2019-Q1
Increased
55
AMRNAMRN
ADR

Amarin Corporation plc

26.5M$115.9M0.5%———
Unchanged
0

GLOBAL BLOOD THERAPEUTICS INC

3.2M$112.7M0.5%——
6 qtrssince 2020-Q1
Unchanged
0

PACIFIC BIOSCIENCES CALIF IN

3.2M$112M0.5%$9.80+267.55%
4 qtrssince 2020-Q3
Unchanged
0
$22.8B
AUM
120
Positions
Q2 2021
Filing
HI score · 3.0/5
Quarterly 13F Value Change
-14%Q1'20$16.2B+40%Q2'20$22.7B+10%Q3'20$25B+6%Q4'20$26.5B-13%Q1'21$23.1B-1%Q2'21$22.8B
Activity profile
$ moved · Q2'21
New9%Increased54%Decreased12%Exited24%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.3 years
<1Q8%1-4Q29%1-2Y27%2Y+37%

BAKER BROS. ADVISORS LP manages $22.8B across 120 positions as of Q2 2021. Top holdings: SGEN (32.8%), ONC (17.6%), INCY (11.8%). Fund DNA: Concentrated Value. HoldingsIntel Score: 3/5.0.

Q2 2021 Summary

Active quarter - 9 new positions, 15 exits, 17 increased. Top move: KOD (INCREASED, conviction 63). Portfolio: $22.8B across 120 positions.

Top holdings by portfolio weight

Total AUM$23B
SGEN32.79%
ONC17.59%
INCY11.83%
KOD5.77%
ACAD4.49%
BMRN2.78%
ASND2.05%
NVTAQ1.52%
ARGX1.48%
PRLD1.27%
Other1.15%

Portfolio allocation by GICS sector

Sectors4
Healthcare60.37%
Unknown39.62%
Consumer Cyclical0.01%
Financial Services0.00%

Behavioral investing profile

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Concentrated Value- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Solid(3.0 / 5.0)
Holdings P&L50
Conviction36
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
7Q
INCYINCYINCYTE CORP
Q4 2024 → Q2 2026+23,310 shares+$1.5B
5Q
IDYAIDYAIDEAYA BIOSCIENCES INC
Q2 2025 → Q2 2026+3.9M shares+$169.3M
3Q
DSGNDSGNDESIGN THERAPEUTICS INC
Q4 2025 → Q2 2026+965,548 shares+$25.9M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

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