BAKER BROS. ADVISORS LPBAKER BROS. ADVISORS LP

Institutional investor · Portfolio as of Q2 2023

Top Holdings107 positions

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Activity:
SGENSGENDelisted

SEAGEN INC

44.6M$8.6B49.6%——
12 qtrssince 2020-Q3
Decreased
0

INCYTE CORP

36.2M$2.3B13.0%$84.99-26.76%
18 qtrssince 2019-Q1
Increased
62
ONCONC
ADR

BEIGENE LTD-ADR

11.7M$2.1B12.0%$149.70+19.11%
18 qtrssince 2019-Q1
Unchanged
0

ACADIA PHARMACEUTICALS INC

42.9M$1B5.9%$27.49-12.88%
18 qtrssince 2019-Q1
Increased
63

MADRIGAL PHARMACEUTICALS INC

1.5M$356.9M2.1%$117.67+96.31%
18 qtrssince 2019-Q1
Unchanged
0

BIOMARIN PHARMACEUTICAL INC

3.8M$330.3M1.9%$88.78+0.17%
18 qtrssince 2019-Q1
Unchanged
0
IMCRIMCR
ADR

IMMUNOCORE HLDGS PLC

2.5M$151.1M0.9%$43.20+33.15%
10 qtrssince 2021-Q1
Unchanged
0
??Invitae CorporationDelisted
Bond
300M$135M0.8%———
New
59

KODIAK SCIENCES INC

17.3M$119.4M0.7%$34.00-79.71%
18 qtrssince 2019-Q1
Unchanged
0
AKROAKRODelisted

AKERO THERAPEUTICS INC

2.4M$110.6M0.6%$29.88+49.41%
12 qtrssince 2020-Q3
Unchanged
0
ARGXARGX
ADR

ARGENX SE - ADR

280,159$109.2M0.6%$138.29+181.83%
18 qtrssince 2019-Q1
Unchanged
0

RHYTHM PHARMACEUTICALS INC

6.5M$107.2M0.6%$24.20-31.87%
18 qtrssince 2019-Q1
Unchanged
0

REPLIMUNE GROUP INC

4.6M$106.3M0.6%$19.94+15.91%
13 qtrssince 2020-Q2
Unchanged
0

ABCELLERA BIOLOGICS INC

16.5M$106.3M0.6%$28.51-76.92%
11 qtrssince 2020-Q4
Increased
60

KYMERA THERAPEUTICS INC

4.4M$100.6M0.6%$30.27-24.04%
12 qtrssince 2020-Q3
Increased
59

ROIVANT SCIENCES LTD

9.4M$95M0.6%$8.64+14.59%
3 qtrssince 2022-Q4
Increased
68

BIOCRYST PHARMACEUTICALS INC

12.7M$89.5M0.5%$7.50-7.15%
18 qtrssince 2019-Q1
Unchanged
0

SPRINGWORKS THERAPEUTICS INC

3M$78.7M0.5%——
3 qtrssince 2022-Q4
Increased
39

ENTRADA THERAPEUTICS INC

4.9M$73.7M0.4%$18.19-17.21%
7 qtrssince 2021-Q4
Unchanged
0

REVOLUTION MEDICINES INC

2.7M$72M0.4%$23.32+12.46%
10 qtrssince 2021-Q1
Unchanged
0
$17.3B
AUM
107
Positions
Q2 2023
Filing
HI score · 3.5/5
Quarterly 13F Value Change
-15%Q1'22$17.4B+1%Q2'22$17.6B-13%Q3'22$15.3B+9%Q4'22$16.7B+10%Q1'23$18.4B-6%Q2'23$17.3B
Activity profile
$ moved · Q2'23
New10%Increased41%Decreased47%Exited2%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 2.2 years
<1Q8%1-4Q21%1-2Y13%2Y+58%

BAKER BROS. ADVISORS LP manages $17.3B across 107 positions as of Q2 2023. Top holdings: SGEN (49.6%), INCY (13.0%), ONC (12.0%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 3.5/5.0.

Q2 2023 Summary

Active quarter - 10 new positions, 8 exits, 20 increased. Top move: ROIV (INCREASED, conviction 68). Portfolio: $17.3B across 107 positions.

Top holdings by portfolio weight

Total AUM$17B
SGEN49.63%
INCY13.03%
ONC12.04%
ACAD5.94%
MDGL2.07%
BMRN1.91%
IMCR0.87%
Invitae Corp0.78%
KOD0.69%
AKRO0.64%
Other0.63%

Portfolio allocation by GICS sector

Sectors3
Unknown53.10%
Healthcare46.88%
Financial Services0.02%

Behavioral investing profile

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Balanced Allocator- primarily Unknown, Healthcare
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Strong(3.5 / 5.0)
Holdings P&L51
Conviction36
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
7Q
INCYINCYIncyte Corp
Q4 2024 → Q2 2026+23,310 shares+$1.5B
5Q
IDYAIDYAIDEAYA BIOSCIENCES INC
Q2 2025 → Q2 2026+3.9M shares+$169.3M
3Q
DSGNDSGNDESIGN THERAPEUTICS INC
Q4 2025 → Q2 2026+965,548 shares+$25.9M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

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