BAKER BROS. ADVISORS LP
Institutional investor · Portfolio as of Q2 2025
Top Holdings89 positions
BEONE MEDICINES LTD | 8.8M | $2.1B | 20.7% | $149.70 | +61.71% | 26 qtrssince 2019-Q1 | Unchanged 0 |
INCYTE CORP | 30.7M | $2.1B | 20.3% | $84.99 | -19.87% | 26 qtrssince 2019-Q1 | Increased 62 |
ACADIA PHARMACEUTICALS INC | 42.9M | $925.3M | 9.0% | $27.48 | -21.52% | 26 qtrssince 2019-Q1 | Increased 62 |
INSMED INC | 7.7M | $776.2M | 7.5% | $76.23 | +32.02% | 26 qtrssince 2019-Q1 | Increased 83 |
SUMMIT THERAPEUTICS INC | 33.7M | $717.6M | 7.0% | $11.80 | +74.63% | 5 qtrssince 2024-Q2 | Increased 81 |
MADRIGAL PHARMACEUTICALS INC | 2M | $598M | 5.8% | $142.64 | +112.18% | 26 qtrssince 2019-Q1 | Increased 61 |
RHYTHM PHARMACEUTICALS INC | 5.6M | $354.1M | 3.4% | $24.17 | +161.49% | 26 qtrssince 2019-Q1 | Unchanged 0 |
REVOLUTION MEDICINES INC | 9.4M | $344.5M | 3.3% | $29.89 | +23.47% | 18 qtrssince 2021-Q1 | Increased 67 |
KYMERA THERAPEUTICS INC | 6.7M | $290.3M | 2.8% | $29.76 | +46.63% | 20 qtrssince 2020-Q3 | Increased 59 |
ALKERMES PLC | 6.4M | $183.4M | 1.8% | $25.88 | +10.57% | 5 qtrssince 2024-Q2 | Increased 65 |
REPLIMUNE GROUP INC | 11M | $102.6M | 1.0% | $13.45 | -30.92% | 21 qtrssince 2020-Q2 | Unchanged 0 |
ULTRAGENYX PHARMACEUTICAL IN | 2.8M | $100.8M | 1.0% | $56.11 | -34.91% | 19 qtrssince 2020-Q4 | Increased 64 |
EDGEWISE THERAPEUTICS INC | 7.3M | $95.8M | 0.9% | $15.71 | -16.16% | 18 qtrssince 2021-Q1 | Increased 50 |
ABCELLERA BIOLOGICS INC | 27.5M | $94.4M | 0.9% | $18.96 | -80.96% | 19 qtrssince 2020-Q4 | Unchanged 0 |
IMMUNOVANT INC | 5.5M | $87.3M | 0.8% | $21.82 | -26.21% | 8 qtrssince 2023-Q3 | Unchanged 0 |
GRAIL INC | 1.6M | $83.8M | 0.8% | $18.64 | +159.60% | 3 qtrssince 2024-Q4 | Unchanged 0 |
KINIKSA PHARMACEUTICALS INTL | 2.8M | $78.2M | 0.8% | $18.69 | +48.05% | 5 qtrssince 2024-Q2 | Increased 42 |
BICYCLE THERAPEUTICS PLC | 10.9M | $75.7M | 0.7% | $20.84 | -65.26% | 12 qtrssince 2022-Q3 | Unchanged 0 |
IMMUNOCORE HLDGS PLC | 2.3M | $72.9M | 0.7% | $38.09 | -17.61% | 18 qtrssince 2021-Q1 | Unchanged 0 |
CELCUITY INC | 5.5M | $72.8M | 0.7% | $13.54 | -7.41% | 8 qtrssince 2023-Q3 | Increased 52 |
BAKER BROS. ADVISORS LP manages $10.3B across 89 positions as of Q2 2025. Top holdings: ONC (20.7%), INCY (20.3%), ACAD (9.0%). Fund DNA: Concentrated Value. HoldingsIntel Score: 3/5.0.
Active quarter - 12 new positions, 12 exits, 23 increased. Top move: INSM (INCREASED, conviction 83). Portfolio: $10.3B across 89 positions.
Top holdings by portfolio weight
Portfolio allocation by GICS sector
Behavioral investing profile
Position Outcomes
Best and worst performing positions by estimated return
Top Winners
Top Losers
Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer
Verify source filings on SEC EDGAR