BAKER BROS. ADVISORS LPBAKER BROS. ADVISORS LP

Institutional investor · Portfolio as of Q3 2020

SEC EDGAR SourceSEC Filings

Top Holdings120 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction
SGENSGENDelisted

SEAGEN INC

47.3M$9.3B37.0%
1 qtr
New
98
ONCONC
ADR

BEIGENE LTD-ADR

13.3M$3.8B15.2%$149.13+88.74%
7 qtrssince 2019-Q1
Increased
70

INCYTE CORP

32M$2.9B11.5%$86.02+1.64%
7 qtrssince 2019-Q1
Increased
62

ACADIA Pharmaceuticals Inc.

41.9M$1.7B6.9%$27.58+46.50%
7 qtrssince 2019-Q1
Unchanged
0
ALXNALXNDelisted

ALEXION PHARMACEUTICALS INC

8.8M$1B4.0%
7 qtrssince 2019-Q1
Unchanged
0

Kodiak Sciences, Inc.

12.4M$731.4M2.9%$22.02+169.13%
7 qtrssince 2019-Q1
Increased
58

BIOMARIN PHARMACEUTICAL INC

7.6M$577.4M2.3%$88.83-14.44%
7 qtrssince 2019-Q1
Unchanged
0
ASNDASND
ADR

ASCENDIS PHARMA A/S

3.5M$546.3M2.2%$119.16+27.77%
7 qtrssince 2019-Q1
Increased
56
NVTAQNVTAQDelisted

INVITAE CORP

11.9M$513.7M2.1%
7 qtrssince 2019-Q1
Unchanged
0
MYOKMYOKDelisted

MYOKARDIA INC

3M$410.3M1.6%
7 qtrssince 2019-Q1
Decreased
0

PRELUDE THERAPEUTICS INC

10.1M$304.9M1.2%$28.840.00%
1 qtr
New
71
ARGXARGX
ADR

ARGENX SE - ADR

1M$267.7M1.1%$124.84+110.29%
7 qtrssince 2019-Q1
Unchanged
0
MRTXMRTXDelisted

MIRATI THERAPEUTICS INC

1.4M$234.1M0.9%
7 qtrssince 2019-Q1
Unchanged
0
IGMSIGMSDelisted

IGM BIOSCIENCES INC

3.1M$232.1M0.9%
5 qtrssince 2019-Q3
Increased
43
EXASEXASDelisted

EXACT SCIENCES CORP

1.8M$188.2M0.8%$91.87
4 qtrssince 2019-Q4
Unchanged
0

MADRIGAL PHARMACEUTICALS INC

1.5M$178M0.7%$113.12+5.39%
7 qtrssince 2019-Q1
Increased
43
AMRNAMRN
ADR

Amarin Corporation plc

32M$134.8M0.5%

HERON THERAPEUTICS INC

6M$88.8M0.4%$23.47-36.76%
7 qtrssince 2019-Q1
Decreased
0
FMTXFMTXDelisted

FORMA THERAPEUTICS HLDGS INC

1.8M$88.3M0.4%
2 qtrssince 2020-Q2
Decreased
0

CERUS CORP

13.7M$85.8M0.3%$5.89+7.76%
7 qtrssince 2019-Q1
Unchanged
0
$25B
AUM
120
Positions
Q3 2020
Filing
Rating · 3.5
Quarterly Portfolio Change
-6%Q2'19$14.7B-0%Q3'19$14.7B+28%Q4'19$18.8B-14%Q1'20$16.2B+40%Q2'20$22.7B+10%Q3'20$25B
Activity profile
$ moved · Q3'20
New47%Increased11%Decreased2%Exited39%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.1 years
<1Q12%1-4Q27%1-2Y53%2Y+9%

BAKER BROS. ADVISORS LP manages $25B across 120 positions as of Q3 2020. Top holdings: SGEN (37.0%), ONC (15.2%), INCY (11.5%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3.5/5.0.

Q3 2020 Summary

Active quarter - 14 new positions, 8 exits, 16 increased. Top move: SGEN (NEW, conviction 98). Portfolio: $25.0B across 120 positions.

Top holdings by portfolio weight

Total AUM$25B
SGEN36.96%
ONC15.22%
INCY11.47%
ACAD6.91%
ALXN4.01%
KOD2.92%
BMRN2.31%
ASND2.18%
NVTAQ2.05%
MYOK1.64%
Other1.22%

Portfolio allocation by GICS sector

Sectors3
Healthcare50.97%
Unknown49.03%
Financial Services0.00%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension quality assessment
Strong(3.5 / 5.0)
Track Record66
Conviction39
Concentration100
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

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Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
8Q
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Q3 2024 Q2 2026+23,806 shares+$1.6B
5Q
IDYAIDYAIDEAYA BIOSCIENCES INC
Q2 2025 Q2 2026+3.9M shares+$169.3M
3Q
DSGNDSGNDESIGN THERAPEUTICS INC
Q4 2025 Q2 2026+965,548 shares+$25.9M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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