RTW INVESTMENTS, LPRTW INVESTMENTS, LP

Institutional investor · Portfolio as of Q2 2022

Top Holdings107 positions

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Activity:

ALNYLAM PHARMACEUTICALS INC

1.7M$245.5M6.3%$94.58+53.76%
14 qtrssince 2019-Q1
Unchanged
0

Thermo Fisher Scientific Inc

435,500$236.6M6.1%$570.15-6.94%
4 qtrssince 2021-Q3
Increased
69

ROCKET PHARMACEUTICALS INC

15.8M$217.4M5.6%$18.70-30.32%
14 qtrssince 2019-Q1
Unchanged
0

PTC THERAPEUTICS INC

5M$202.1M5.2%$41.64-2.98%
14 qtrssince 2019-Q1
Decreased
0
MASIMASIDelisted

MASIMO CORP

1.4M$176.5M4.6%$177.58-23.35%
14 qtrssince 2019-Q1
Increased
66
ARGXARGX
ADR

ARGENX SE

442,635$167.7M4.3%$327.56+15.67%
14 qtrssince 2019-Q1
Increased
71
IMCRIMCR
ADR

IMMUNOCORE HLDGS PLC ADS

4M$149.1M3.9%$37.22-3.55%
6 qtrssince 2021-Q1
Increased
90

ESTABLISHMENT LABS HLDGS INC COM

2.4M$128.8M3.3%$22.63+149.35%
14 qtrssince 2019-Q1
Increased
56
MRTXMRTXDelisted

MIRATI THERAPEUTICS INC

1.9M$126.4M3.3%——
14 qtrssince 2019-Q1
Increased
66

ILLUMINA INC

564,375$104M2.7%$320.70-43.45%
8 qtrssince 2020-Q3
Increased
57

CYTOKINETICS INC COM NEW

2.6M$100.6M2.6%$26.89+46.10%
8 qtrssince 2020-Q3
Unchanged
0
RXDXRXDXDelisted

PROMETHEUS BIOSCIENCES INC

3.2M$90M2.3%——
6 qtrssince 2021-Q1
Increased
59

Vericel Corporation

3.5M$88.7M2.3%$17.25+46.82%
14 qtrssince 2019-Q1
Decreased
0

Penumbra Inc.

698,371$87M2.2%$262.94-50.46%
4 qtrssince 2021-Q3
Increased
54

CELLDEX THERAPEUTICS INC NEW COM NEW

3.1M$83.2M2.1%$14.23+95.53%
9 qtrssince 2020-Q2
Unchanged
0

ULTRAGENYX PHARMACEUTICAL INC COM

1.4M$81.9M2.1%$84.09-29.05%
3 qtrssince 2021-Q4
Unchanged
0

NATERA INC

2.1M$75.2M1.9%$43.21-17.97%
12 qtrssince 2019-Q3
Increased
52
RNAMRNAMDelisted

AVIDITY BIOSCIENCES INC

4.8M$69.7M1.8%$26.39-45.81%
9 qtrssince 2020-Q2
Unchanged
0
AXNXAXNXDelisted

AXONICS INC

1.2M$66.9M1.7%——
14 qtrssince 2019-Q1
Decreased
0
CUTRQCUTRQDelisted

CUTERA INC

1.8M$66.4M1.7%——
5 qtrssince 2021-Q2
Increased
54
$3.9B
AUM
107
Positions
Q2 2022
Filing
HI score · 3.0/5
Quarterly 13F Value Change
+7%Q1'21$6.4B+3%Q2'21$6.6B+0%Q3'21$6.6B+3%Q4'21$6.8B-29%Q1'22$4.8B-20%Q2'22$3.9B
Activity profile
$ moved · Q2'22
New12%Increased52%Decreased30%Exited5%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.5 years
<1Q8%1-4Q25%1-2Y34%2Y+33%

RTW INVESTMENTS, LP manages $3.9B across 107 positions as of Q2 2022. Top holdings: ALNY (6.3%), TMO (6.1%), RCKT (5.6%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 3/5.0.

Q2 2022 Summary

Active quarter - 10 new positions, 9 exits, 28 increased. Top move: IMCR (INCREASED, conviction 90). Portfolio: $3.9B across 107 positions.

Top holdings by portfolio weight

Total AUM$4B
ALNY6.34%
TMO6.11%
RCKT5.62%
PTCT5.22%
MASI4.56%
ARGX4.33%
IMCR3.85%
ESTA3.33%
MRTX3.27%
ILMN2.69%
Other2.60%

Portfolio allocation by GICS sector

Sectors3
Healthcare83.75%
Unknown15.98%
Industrials0.27%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Solid(3.0 / 5.0)
Holdings P&L53
Conviction44
Concentration72
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
7Q
RDNTRDNTRADNET INC COM
Q4 2024 → Q2 2026+3M shares+$173.4M
6Q
CMPSCMPSCOMPASS PATHWAYS PLC SPONSORED ADS
Q1 2025 → Q2 2026+7.6M shares+$139.7M
6Q
IMTXIMTXIMMATICS N.V SHS
Q1 2025 → Q2 2026+6.4M shares+$84.6M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

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