RTW INVESTMENTS, LPRTW INVESTMENTS, LP

Institutional investor · Portfolio as of Q3 2022

Top Holdings86 positions

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Activity:

Alnylam Pharmaceuticals Inc

1.7M$336.9M7.8%$94.58+121.39%
15 qtrssince 2019-Q1
Unchanged
0

PTC Therapeutics Inc

5.6M$282.2M6.5%$42.53+18.38%
15 qtrssince 2019-Q1
Increased
67

Rocket Pharmaceuticals Inc

15.8M$252.2M5.8%$18.70-24.92%
15 qtrssince 2019-Q1
Unchanged
0

Thermo Fisher Scientific Inc

435,500$220.9M5.1%$570.15-10.24%
5 qtrssince 2021-Q3
Unchanged
0
IMCRIMCR
ADR

IMMUNOCORE HLDGS PLC

4.5M$209M4.8%$38.10+20.30%
7 qtrssince 2021-Q1
Increased
63
MASIMASIDelisted

Masimo Corp

1.4M$203.3M4.7%$175.41-18.81%
15 qtrssince 2019-Q1
Increased
60
RXDXRXDXDelisted

PROMETHEUS BIOSCIENCES INC

3.2M$188.2M4.3%——
7 qtrssince 2021-Q1
Unchanged
0
ARGXARGX
ADR

ARGENX SE-ADR

467,195$164.9M3.8%$328.90+7.34%
15 qtrssince 2019-Q1
Increased
59

Penumbra Inc

698,371$132.4M3.1%$262.94-27.05%
5 qtrssince 2021-Q3
Unchanged
0
MRTXMRTXDelisted

Mirati Therapeutics Inc

1.9M$131.5M3.0%——
15 qtrssince 2019-Q1
Unchanged
0

ESTABLISHMENT LABS HLDGS INC

2.4M$129.4M3.0%$22.63+133.75%
15 qtrssince 2019-Q1
Unchanged
0

Cytokinetics Inc

2.6M$124.7M2.9%$27.00+79.43%
9 qtrssince 2020-Q3
Increased
52

Illumina Inc

564,375$107.7M2.5%$320.70-41.21%
9 qtrssince 2020-Q3
Unchanged
0

Relmada Therapeutics Inc

2.6M$97.9M2.3%$32.16+12.54%
12 qtrssince 2019-Q4
Increased
51

Ultragenyx Pharmaceutical Inc

2.4M$97.7M2.3%$66.25-37.49%
4 qtrssince 2021-Q4
Increased
77

NATERA INC

2.2M$96.8M2.2%$43.23+1.36%
13 qtrssince 2019-Q3
Increased
53

CELLDEX THERAPEUTICS INC NEW

3.1M$86.7M2.0%$14.23+99.18%
10 qtrssince 2020-Q2
Unchanged
0
RNAMRNAMDelisted

AVIDITY BIOSCIENCES INC

5.2M$84.4M1.9%$25.69-34.90%
10 qtrssince 2020-Q2
Increased
51

AXSOME THERAPEUTICS INC

1.9M$84M1.9%$48.56-9.09%
15 qtrssince 2019-Q1
Increased
54
CUTRQCUTRQDelisted

Cutera Inc

1.8M$80.7M1.9%——
6 qtrssince 2021-Q2
Unchanged
0
$4.3B
AUM
86
Positions
Q3 2022
Filing
HI score · 3.5/5
Quarterly 13F Value Change
+3%Q2'21$6.6B+0%Q3'21$6.6B+3%Q4'21$6.8B-29%Q1'22$4.8B-20%Q2'22$3.9B+12%Q3'22$4.3B
Activity profile
$ moved · Q3'22
New12%Increased45%Decreased22%Exited21%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.9 years
<1Q3%1-4Q12%1-2Y41%2Y+44%

RTW INVESTMENTS, LP manages $4.3B across 86 positions as of Q3 2022. Top holdings: ALNY (7.8%), PTCT (6.5%), RCKT (5.8%). Fund DNA: Balanced Allocator. HoldingsIntel Score: 3.5/5.0.

Q3 2022 Summary

Active quarter - 4 new positions, 25 exits, 17 increased. Top move: RARE (INCREASED, conviction 77). Portfolio: $4.3B across 86 positions.

Top holdings by portfolio weight

Total AUM$4B
ALNY7.77%
PTCT6.50%
RCKT5.81%
TMO5.09%
IMCR4.82%
MASI4.69%
RXDX4.34%
ARGX3.80%
PEN3.05%
MRTX3.03%
Other2.98%

Portfolio allocation by GICS sector

Sectors2
Healthcare81.09%
Unknown18.91%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension, SEC 13F-derived research score
Strong(3.5 / 5.0)
Holdings P&L53
Conviction44
Concentration72
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
7Q
RDNTRDNTRADNET INC COM
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6Q
CMPSCMPSCOMPASS PATHWAYS PLC SPONSORED ADS
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6Q
IMTXIMTXIMMATICS N.V SHS
Q1 2025 → Q2 2026+6.4M shares+$84.6M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

Verify source filings on SEC EDGAR

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