RTW INVESTMENTS, LPRTW INVESTMENTS, LP

Institutional investor · Portfolio as of Q2 2024

SEC EDGAR SourceSEC Filings

Top Holdings68 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction

MADRIGAL PHARMACEUTICALS INC

1.9M$536.7M8.3%$267.51+4.73%
5 qtrssince 2023-Q2
Increased
98

ROCKET PHARMACEUTICALS INC

17.7M$380.8M5.9%$18.79+14.56%
22 qtrssince 2019-Q1
Unchanged
0

AXSOME THERAPEUTICS INC

4.6M$373.1M5.8%$62.01+29.81%
22 qtrssince 2019-Q1
Increased
62
8.8M$359.8M5.6%$25.64+59.33%
17 qtrssince 2020-Q2
Increased
67
ARGXARGX
ADR

ARGENX SE - ADR

654,430$281.4M4.4%$348.48+23.41%
22 qtrssince 2019-Q1
Decreased
0

NATERA INC

2.6M$280.8M4.3%$42.12+157.13%
20 qtrssince 2019-Q3
Unchanged
0
MRUSMRUSDelisted

MERUS N V

4.2M$246.7M3.8%$34.06+73.74%
5 qtrssince 2023-Q2
Increased
57

INSMED INC

3.6M$243.9M3.8%$44.25+51.40%
5 qtrssince 2023-Q2
Increased
90

PTC THERAPEUTICS INC

7.4M$226.1M3.5%$43.39-29.52%
22 qtrssince 2019-Q1
Decreased
0

DYNE THERAPEUTICS INC

6.4M$225.4M3.5%$31.95+10.45%
2 qtrssince 2024-Q1
Increased
91

ACADIA Pharmaceuticals Inc.

13.7M$222.7M3.4%$18.35-11.44%
9 qtrssince 2022-Q2
Decreased
0

BRUKER CORP

3.4M$219.8M3.4%$72.35-12.39%
6 qtrssince 2023-Q1
Increased
58
MASIMASIDelisted

MASIMO CORP

1.5M$184.2M2.9%$174.28-27.74%
22 qtrssince 2019-Q1
Unchanged
0

PROTAGONIST THERAPEUTICS INC

5.3M$183.2M2.8%$22.38+54.80%
20 qtrssince 2019-Q3
Decreased
0

ALKERMES PLC

7.1M$170.1M2.6%$27.05-10.91%
4 qtrssince 2023-Q3
Increased
60
IMCRIMCR
ADR

IMMUNOCORE HLDGS PLC

4.9M$165M2.6%$43.05-21.28%
14 qtrssince 2021-Q1
Decreased
0

CYTOKINETICS INC

2.7M$147.4M2.3%$28.96+87.08%
16 qtrssince 2020-Q3
Increased
56

Ultragenyx Pharmaceutical, Inc.

3.3M$134M2.1%$52.92-22.33%
11 qtrssince 2021-Q4
Decreased
0

PENUMBRA INC

742,105$133.6M2.1%$254.83-29.38%
12 qtrssince 2021-Q3
Increased
57
AKROAKRODelisted

AKERO THERAPEUTICS INC

5.4M$127.4M2.0%$24.00-2.24%
3 qtrssince 2023-Q4
Unchanged
0
$6.5B
AUM
68
Positions
Q2 2024
Filing
Rating · 3.0
Quarterly Portfolio Change
-2%Q1'23$4.8B+9%Q2'23$5.3B-10%Q3'23$4.7B+35%Q4'23$6.4B+6%Q1'24$6.8B-5%Q2'24$6.5B
Activity profile
$ moved · Q2'24
New2%Increased54%Decreased26%Exited18%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 2.3 years
<1Q9%1-4Q29%1-2Y10%2Y+51%

RTW INVESTMENTS, LP manages $6.5B across 68 positions as of Q2 2024. Top holdings: MDGL (8.3%), RCKT (5.9%), AXSM (5.8%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3/5.0.

Q2 2024 Summary

Active quarter - 7 new positions, 8 exits, 23 increased. Top move: MDGL (INCREASED, conviction 98). Portfolio: $6.5B across 68 positions.

Top holdings by portfolio weight

Total AUM$6B
MDGL8.31%
RCKT5.90%
AXSM5.78%
RNAM5.57%
ARGX4.36%
NTRA4.35%
MRUS3.82%
INSM3.78%
PTCT3.50%
DYN3.49%
Other3.45%

Portfolio allocation by GICS sector

Sectors3
Healthcare94.56%
Unknown5.33%
Financial Services0.12%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare
Compare DNA across all funds
7-dimension quality assessment
Solid(3.0 / 5.0)
Track Record36
Conviction45
Concentration72
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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