RTW INVESTMENTS, LP
Institutional investor · Portfolio as of Q1 2025
Top Holdings68 positions
Stock | Shares | Value | Weight | Avg Buy | Est. P&L | Held | Conviction |
|---|---|---|---|---|---|---|---|
MADRIGAL PHARMACEUTICALS INC | 2M | $660.4M | 10.1% | $265.36 | +23.55% | 8 qtrssince 2023-Q2 | Unchanged 0 |
ARGENX SE - ADR | 673,497 | $398.6M | 6.1% | $356.02 | +66.24% | 25 qtrssince 2019-Q1 | Unchanged 0 |
PTC THERAPEUTICS INC | 7.5M | $381.3M | 5.8% | $43.52 | +24.64% | 25 qtrssince 2019-Q1 | Increased 61 |
NATERA INC | 2.6M | $366.8M | 5.6% | $42.12 | +241.71% | 23 qtrssince 2019-Q3 | Increased 60 |
AXSOME THERAPEUTICS INC | 2.9M | $340.9M | 5.2% | $62.01 | +91.14% | 25 qtrssince 2019-Q1 | Decreased 0 |
AKERO THERAPEUTICS INC | 7.4M | $300.3M | 4.6% | $26.19 | +63.12% | 6 qtrssince 2023-Q4 | Increased 61 |
PROTAGONIST THERAPEUTICS INC | 5.7M | $276.6M | 4.2% | $24.15 | +102.38% | 23 qtrssince 2019-Q3 | Increased 59 |
| 8.7M | $258.2M | 3.9% | $26.19 | +20.64% | 20 qtrssince 2020-Q2 | Increased 62 | |
PENUMBRA INC | 862,770 | $230.7M | 3.5% | $249.61 | +7.19% | 15 qtrssince 2021-Q3 | Increased 56 |
INSMED INC | 3M | $230M | 3.5% | $44.25 | +76.23% | 8 qtrssince 2023-Q2 | Unchanged 0 |
ALKERMES PLC | 6.9M | $227.3M | 3.5% | $27.26 | +21.14% | 7 qtrssince 2023-Q3 | Decreased 0 |
STRYKER CORP | 590,221 | $219.7M | 3.4% | $356.25 | +1.38% | 3 qtrssince 2024-Q3 | Unchanged 0 |
VERONA PHARMA PLC | 2.8M | $180.9M | 2.8% | — | — | 2 qtrssince 2024-Q4 | Increased 74 |
MERUS N V | 4.2M | $175.5M | 2.7% | $34.06 | +30.99% | 8 qtrssince 2023-Q2 | Unchanged 0 |
TARSUS PHARMACEUTICALS INC | 3.3M | $170.3M | 2.6% | $33.23 | +55.69% | 18 qtrssince 2020-Q4 | Increased 53 |
IMMUNOCORE HLDGS PLC | 4.9M | $144.5M | 2.2% | $43.05 | -31.29% | 17 qtrssince 2021-Q1 | Unchanged 0 |
ACADIA Pharmaceuticals Inc. | 8.5M | $141.9M | 2.2% | $18.35 | -6.97% | 12 qtrssince 2022-Q2 | Decreased 0 |
ROCKET PHARMACEUTICALS INC | 17.7M | $118M | 1.8% | $18.79 | -59.61% | 25 qtrssince 2019-Q1 | Unchanged 0 |
RadNet, Inc. | 2.3M | $115.2M | 1.8% | $47.21 | +4.73% | 6 qtrssince 2023-Q4 | Increased 55 |
MASIMO CORP | 683,294 | $113.8M | 1.7% | $174.28 | -6.16% | 25 qtrssince 2019-Q1 | Unchanged 0 |
RTW INVESTMENTS, LP manages $6.5B across 68 positions as of Q1 2025. Top holdings: MDGL (10.1%), ARGX (6.1%), PTCT (5.8%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3/5.0.
Active quarter - 10 new positions, 14 exits, 17 increased. Top move: VRNA (INCREASED, conviction 74). Portfolio: $6.5B across 68 positions.
Top holdings by portfolio weight
Portfolio allocation by GICS sector
Behavioral investing profile
Position Outcomes
Best and worst performing positions by estimated return
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Top Losers
Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer