RA CAPITAL MANAGEMENT, L.P.RA CAPITAL MANAGEMENT, L.P.

Institutional investor · Portfolio as of Q1 2022

SEC EDGAR SourceSEC Filings

Top Holdings96 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction
ASNDASND
ADR

ASCENDIS PHARMA A/S

7.6M$888.2M19.4%$95.96+20.90%
14 qtrssince 2018-Q4
Unchanged
0

BIOGEN IDEC INC

727,024$153.1M3.3%$211.030.00%
1 qtr
New
84
8.3M$151.5M3.3%
4 qtrssince 2021-Q2
Unchanged
0

CYTEK BIOSCIENCES INC

13.4M$144.2M3.1%$18.15-39.44%
3 qtrssince 2021-Q3
Increased
73
ITOSITOSDelisted

ITEOS THERAPEUTICS INC

4.4M$142.1M3.1%
7 qtrssince 2020-Q3
Unchanged
0

TRAVERE THERAPEUTICS INC

4.9M$126.9M2.8%$26.96-6.86%
6 qtrssince 2020-Q4
Decreased
0

JANUX THERAPEUTICS INC

8.7M$124.3M2.7%$25.37-42.57%
4 qtrssince 2021-Q2
Unchanged
0

VAXCYTE INC

4.6M$110.6M2.4%$29.78-19.17%
8 qtrssince 2020-Q2
Increased
56

CLIMB BIO INC

13.2M$110.3M2.4%$17.23-51.42%
3 qtrssince 2021-Q3
Unchanged
0

IMMUNOGEN INC

21.7M$103.5M2.3%
7 qtrssince 2020-Q3
Increased
55
DICEDICEDelisted

DICE THERAPEUTICS INC

5.2M$99.6M2.2%
3 qtrssince 2021-Q3
Unchanged
0

GH RESEARCH PLC

4.8M$88.3M1.9%$19.84-9.29%
4 qtrssince 2021-Q2
Increased
70
FMTXFMTXDelisted

FORMA THERAPEUTICS HLDGS INC

9M$83.8M1.8%
8 qtrssince 2020-Q2
Unchanged
0

TYRA BIOSCIENCES INC

7.2M$77.4M1.7%$16.91-39.03%
3 qtrssince 2021-Q3
Unchanged
0
PNTPNTDelisted

POINT BIOPHARMA GLOBAL INC

9M$71.8M1.6%
3 qtrssince 2021-Q3
Unchanged
0

Celldex Therapeutics, Inc.

2.1M$70.7M1.5%$48.42-28.56%
3 qtrssince 2021-Q3
Increased
53
BLUBLUDelisted

BELLUS HEALTH INC NEW

10.2M$70.4M1.5%
2 qtrssince 2021-Q4
Unchanged
0

ENANTA PHARMACEUTICALS INC

964,212$68.6M1.5%$69.220.00%
1 qtr
New
68

Vor Biopharma Inc.

11.1M$67.2M1.5%

NKARTA INC

5.6M$63.8M1.4%$30.36-62.38%
7 qtrssince 2020-Q3
Unchanged
0
$4.6B
AUM
96
Positions
Q1 2022
Filing
Rating · 3.0
Quarterly Portfolio Change
+31%Q4'20$7.2B-7%Q1'21$6.6B-6%Q2'21$6.2B+16%Q3'21$7.2B-21%Q4'21$5.7B-19%Q1'22$4.6B
Activity profile
$ moved · Q1'22
New35%Increased19%Decreased24%Exited21%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.1 years
<1Q9%1-4Q40%1-2Y31%2Y+20%

RA CAPITAL MANAGEMENT, L.P. manages $4.6B across 96 positions as of Q1 2022. Top holdings: ASND (19.4%), BIIB (3.3%), AEROVATE THERAPEUTICS INC (3.3%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3/5.0.

Q1 2022 Summary

Active quarter - 10 new positions, 11 exits, 11 increased. Top move: BIIB (NEW, conviction 84). Portfolio: $4.6B across 96 positions.

Top holdings by portfolio weight

Total AUM$5B
ASND19.38%
BIIB3.34%
AEROVATE THE3.31%
CTKB3.15%
ITOS3.10%
TVTX2.77%
JANX2.71%
PCVX2.41%
CLYM2.41%
IMGN2.26%
Other2.17%

Portfolio allocation by GICS sector

Sectors2
Healthcare75.74%
Unknown24.26%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension quality assessment
Solid(3.0 / 5.0)
Track Record65
Conviction42
Concentration91
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
2Q
SLDBSLDBSOLID BIOSCIENCES INC
Q1 2026 Q2 2026+6.2M shares+$87.5M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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