RA CAPITAL MANAGEMENT, L.P.RA CAPITAL MANAGEMENT, L.P.

Institutional investor · Portfolio as of Q4 2019

SEC EDGAR SourceSEC Filings

Top Holdings34 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction
THORTHORDelisted

Synthorx Inc

9.7M$679.7M20.6%
5 qtrssince 2018-Q4
Unchanged
0
ASNDASND
ADR

ASCENDIS PHARMA A/S

4.2M$582.3M17.7%$60.85+123.45%
5 qtrssince 2018-Q4
Increased
63
RARXRARXDelisted

RA PHARMACEUTICALS INC

4.9M$228M6.9%
5 qtrssince 2018-Q4
Unchanged
0

ARVINAS INC

3.7M$150.9M4.6%$29.09+45.34%
5 qtrssince 2018-Q4
Increased
91
3.2M$126.5M3.8%
1 qtr
New
84

RHYTHM PHARMACEUTICALS INC

5.4M$124.5M3.8%$23.88-3.80%
5 qtrssince 2018-Q4
Increased
80
EIDXEIDXDelisted

EIDOS THERAPEUTICS INC

2.2M$124.1M3.8%
5 qtrssince 2018-Q4
Unchanged
0
ZGNXZGNXDelisted

ZOGENIX INC

2.3M$117.9M3.6%
5 qtrssince 2018-Q4
Unchanged
0

PHATHOM PHARMACEUTICALS INC

3.6M$113.6M3.4%$32.500.00%
1 qtr
New
84

TG Therapeutics, Inc.

9.9M$109.7M3.3%$6.07+78.87%
5 qtrssince 2018-Q4
Increased
75
STSASTSADelisted

SATSUMA PHARMACEUTICALS INC

4.7M$92.1M2.8%
2 qtrssince 2019-Q3
Unchanged
0
ORTXORTXDelisted
ADR

ORCHARD THERAPEUTICS PLC

6.4M$87.9M2.7%
ETNBETNBDelisted

89BIO INC

3.2M$83.1M2.5%
1 qtr
New
78
FTSVFTSVDelisted

FORTY SEVEN INC

1.9M$76.1M2.3%
1 qtr
New
78

WAVE LIFE SCIENCES LTD

7.8M$62.3M1.9%$42.17-81.05%
5 qtrssince 2018-Q4
Unchanged
0
??RETROPHIN INCDelisted
4.3M$60.4M1.8%
Increased
51

Boundless Bio, Inc.

902,383$54M1.6%
1 qtr
New
68
PRVLPRVLDelisted

PREVAIL THERAPEUTICS INC

3.4M$53.2M1.6%
3 qtrssince 2019-Q2
Unchanged
0

CRINETICS PHARMACEUTICALS IN

1.9M$47M1.4%$30.51-22.29%
5 qtrssince 2018-Q4
Unchanged
0

ARDELYX INC

5.4M$40.2M1.2%$7.430.00%
1 qtr
New
67
$3.3B
AUM
34
Positions
Q4 2019
Filing
Rating · 3.0
Quarterly Portfolio Change
+35%Q1'19$2.3B-20%Q2'19$1.9B-10%Q3'19$1.7B+96%Q4'19$3.3B
Activity profile
$ moved · Q4'19
New47%Increased41%Decreased2%Exited9%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 2.8 quarters
<1Q24%1-4Q29%1-2Y38%2Y+9%

RA CAPITAL MANAGEMENT, L.P. manages $3.3B across 34 positions as of Q4 2019. Top holdings: THOR (20.6%), ASND (17.7%), RARX (6.9%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3/5.0.

Q4 2019 Summary

Active quarter - 9 new positions, 7 exits, 7 increased. Top move: ARVN (INCREASED, conviction 91). Portfolio: $3.3B across 34 positions.

Top holdings by portfolio weight

Total AUM$3B
THOR20.61%
ASND17.66%
RARX6.91%
ARVN4.58%
CHEMOCENTRYX3.84%
RYTM3.78%
EIDX3.76%
ZGNX3.57%
PHAT3.44%
TGTX3.33%
Other2.79%

Portfolio allocation by GICS sector

Sectors2
Unknown55.27%
Healthcare44.73%

Behavioral investing profile

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Balanced Allocator- primarily Unknown, Healthcare
Compare DNA across all funds
7-dimension quality assessment
Solid(3.0 / 5.0)
Track Record65
Conviction42
Concentration91
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
2Q
SLDBSLDBSOLID BIOSCIENCES INC
Q1 2026 Q2 2026+6.2M shares+$87.5M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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