RA CAPITAL MANAGEMENT, L.P.RA CAPITAL MANAGEMENT, L.P.

Institutional investor · Portfolio as of Q3 2022

SEC EDGAR SourceSEC Filings

Top Holdings81 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction
ASNDASND
ADR

ASCENDIS PHARMA A/S

7.6M$781.5M16.7%$95.96+6.94%
16 qtrssince 2018-Q4
Unchanged
0

BIOGEN IDEC INC

937,549$250.3M5.3%$222.99+18.52%
3 qtrssince 2022-Q1
Increased
75

CYTEK BIOSCIENCES INC

13.4M$197M4.2%$18.15-21.70%
5 qtrssince 2021-Q3
Unchanged
0
FMTXFMTXDelisted

FORMA THERAPEUTICS HLDGS INC

9M$179.8M3.8%
10 qtrssince 2020-Q2
Unchanged
0
DAWNDAWNDelisted

DAY ONE BIOPHARMACEUTICALS I

7M$141M3.0%$19.64-0.08%
6 qtrssince 2021-Q2
Unchanged
0
8.3M$137M2.9%
6 qtrssince 2021-Q2
Unchanged
0

RHYTHM PHARMACEUTICALS INC

5.5M$134M2.9%$23.43+1.89%
16 qtrssince 2018-Q4
Increased
58

TRAVERE THERAPEUTICS INC

4.9M$121.3M2.6%$26.96-8.60%
8 qtrssince 2020-Q4
Unchanged
0
BLUBLUDelisted

BELLUS HEALTH INC NEW

11.4M$120.2M2.6%
4 qtrssince 2021-Q4
Increased
57

JANUX THERAPEUTICS INC

8.7M$117.4M2.5%$25.37-47.30%
6 qtrssince 2021-Q2
Unchanged
0

VAXCYTE INC

4.6M$109.9M2.3%$29.78-16.81%
10 qtrssince 2020-Q2
Unchanged
0
DICEDICEDelisted

DICE THERAPEUTICS INC

5.2M$105.6M2.3%
5 qtrssince 2021-Q3
Unchanged
0

IMMUNOGEN INC

21.7M$103.9M2.2%
9 qtrssince 2020-Q3
Unchanged
0

NKARTA INC

7.8M$102.7M2.2%$25.19-49.86%
9 qtrssince 2020-Q3
Unchanged
0

ACUMEN PHARMACEUTICALS INC

9.8M$98M2.1%$14.85-29.43%
5 qtrssince 2021-Q3
Unchanged
0
LEGNLEGN
ADR

Legend Biotech Corp. Sponsored ADR

2.3M$95.4M2.0%$40.110.00%
1 qtr
New
77
ITOSITOSDelisted

ITEOS THERAPEUTICS INC

4.4M$84.1M1.8%
9 qtrssince 2020-Q3
Unchanged
0

RELMADA THERAPEUTICS INC

2M$74M1.6%$21.71+66.70%
4 qtrssince 2021-Q4
Unchanged
0

PEPGEN INC

8.1M$73.8M1.6%$10.40-19.62%
2 qtrssince 2022-Q2
Unchanged
0

GERON CORP

30.1M$70.5M1.5%$2.10+10.00%
10 qtrssince 2020-Q2
Unchanged
0
$4.7B
AUM
81
Positions
Q3 2022
Filing
Rating · 3.0
Quarterly Portfolio Change
-6%Q2'21$6.2B+16%Q3'21$7.2B-21%Q4'21$5.7B-19%Q1'22$4.6B-18%Q2'22$3.8B+25%Q3'22$4.7B
Activity profile
$ moved · Q3'22
New37%Increased33%Decreased2%Exited27%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 1.4 years
<1Q11%1-4Q16%1-2Y38%2Y+35%

RA CAPITAL MANAGEMENT, L.P. manages $4.7B across 81 positions as of Q3 2022. Top holdings: ASND (16.7%), BIIB (5.3%), CTKB (4.2%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3/5.0.

Q3 2022 Summary

Active quarter - 13 new positions, 20 exits, 10 increased. Top move: LEGN (NEW, conviction 77). Portfolio: $4.7B across 81 positions.

Top holdings by portfolio weight

Total AUM$5B
ASND16.67%
BIIB5.34%
CTKB4.20%
FMTX3.84%
DAWN3.01%
AEROVATE THE2.92%
RYTM2.86%
TVTX2.59%
BLU2.56%
JANX2.50%
Other2.35%

Portfolio allocation by GICS sector

Sectors2
Healthcare74.60%
Unknown25.40%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension quality assessment
Solid(3.0 / 5.0)
Track Record65
Conviction42
Concentration91
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
2Q
SLDBSLDBSOLID BIOSCIENCES INC
Q1 2026 Q2 2026+6.2M shares+$87.5M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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