RA CAPITAL MANAGEMENT, L.P.RA CAPITAL MANAGEMENT, L.P.

Institutional investor · Portfolio as of Q3 2019

SEC EDGAR SourceSEC Filings

Top Holdings32 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction
ASNDASND
ADR

ASCENDIS PHARMA A/S

4.1M$398M23.7%$59.89+60.61%
4 qtrssince 2018-Q4
Unchanged
0

WAVE LIFE SCIENCES LTD

7.8M$159.6M9.5%$42.17-51.70%
4 qtrssince 2018-Q4
Unchanged
0
THORTHORDelisted

Synthorx Inc

9.7M$158.2M9.4%
4 qtrssince 2018-Q4
Unchanged
0
RARXRARXDelisted

RA PHARMACEUTICALS INC

4.9M$114.9M6.8%
4 qtrssince 2018-Q4
Unchanged
0
ZGNXZGNXDelisted

ZOGENIX INC

2.3M$90.5M5.4%
4 qtrssince 2018-Q4
Decreased
0
EIDXEIDXDelisted

EIDOS THERAPEUTICS INC

2.2M$77.8M4.6%
4 qtrssince 2018-Q4
Unchanged
0

RHYTHM PHARMACEUTICALS INC

3.4M$73.9M4.4%$24.41-13.18%
4 qtrssince 2018-Q4
Increased
85
STSASTSADelisted

SATSUMA PHARMACEUTICALS INC

4.7M$70.3M4.2%
1 qtr
New
83
ORTXORTXDelisted
ADR

ORCHARD THERAPEUTICS PLC

5.2M$62.1M3.7%
4.6M$47.3M2.8%
4 qtrssince 2018-Q4
Increased
75
??RETROPHIN INCDelisted
4M$46.2M2.8%
New
77
PRVLPRVLDelisted

PREVAIL THERAPEUTICS INC

3.4M$41.3M2.5%
2 qtrssince 2019-Q2
Increased
61

TG Therapeutics, Inc.

6.9M$38.6M2.3%$3.98+41.96%
4 qtrssince 2018-Q4
Unchanged
0

ARVINAS INC

1.7M$35.8M2.1%$13.16+72.87%
4 qtrssince 2018-Q4
Decreased
0
DRNADRNADelisted

DICERNA PHARMACEUTICALS INC

2.5M$35.3M2.1%
4 qtrssince 2018-Q4
Unchanged
0

MYOVANT SCIENCES LTD

6.2M$32.1M1.9%
4 qtrssince 2018-Q4
Decreased
0

CRINETICS PHARMACEUTICALS IN

1.9M$28.2M1.7%$30.51-50.41%
4 qtrssince 2018-Q4
Unchanged
0

STOKE THERAPEUTICS INC

1.1M$24.1M1.4%$29.17-29.62%
2 qtrssince 2019-Q2
Unchanged
0
SCPHSCPHDelisted

SCPHARMACEUTICALS INC

3.2M$19.1M1.1%
4 qtrssince 2018-Q4
Unchanged
0

KALA BIO, Inc.

4.5M$17.3M1.0%
$1.7B
AUM
32
Positions
Q3 2019
Filing
Rating · 3.0
Quarterly Portfolio Change
+35%Q1'19$2.3B-20%Q2'19$1.9B-10%Q3'19$1.7B
Activity profile
$ moved · Q3'19
New40%Increased17%Decreased33%Exited10%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg 2.7 quarters
<1Q28%1-4Q59%1-2Y0%2Y+13%

RA CAPITAL MANAGEMENT, L.P. manages $1.7B across 32 positions as of Q3 2019. Top holdings: ASND (23.7%), WVE (9.5%), THOR (9.4%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3/5.0.

Q3 2019 Summary

Active quarter - 9 new positions, 2 exits, 4 increased. Top move: RYTM (INCREASED, conviction 85). Portfolio: $1.7B across 32 positions.

Top holdings by portfolio weight

Total AUM$2B
ASND23.72%
WVE9.51%
THOR9.43%
RARX6.85%
ZGNX5.39%
EIDX4.63%
RYTM4.40%
STSA4.19%
ORTX3.70%
SLDBN2.82%
Other2.75%

Portfolio allocation by GICS sector

Sectors2
Healthcare52.22%
Unknown47.78%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension quality assessment
Solid(3.0 / 5.0)
Track Record65
Conviction42
Concentration91
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Position Outcomes

Best and worst performing positions by estimated return

Cost basis estimates based on full filing history using quarter-end prices. Actual transaction prices are not disclosed in 13F filings.

Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
2Q
SLDBSLDBSOLID BIOSCIENCES INC
Q1 2026 Q2 2026+6.2M shares+$87.5M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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