RA CAPITAL MANAGEMENT, L.P.RA CAPITAL MANAGEMENT, L.P.

Institutional investor · Portfolio as of Q4 2018

SEC EDGAR SourceSEC Filings

Top Holdings25 positions

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Activity:
Stock
Shares
Value
Weight
Avg Buy
Est. P&L
Held
Conviction

WAVE LIFE SCIENCES LTD

7.5M$315.8M18.4%$42.290.00%
1 qtr
New
97
ASNDASND
ADR

ASCENDIS PHARMA A/S

4.2M$265.7M15.5%$59.890.00%
1 qtr
New
96
THORTHORDelisted

Synthorx Inc

9.7M$169M9.8%
1 qtr
New
95
ZGNXZGNXDelisted

ZOGENIX INC

2.4M$86.9M5.1%
1 qtr
New
93

BIOCRYST PHARMACEUTICALS INC

10.7M$86M5.0%$7.880.00%
1 qtr
New
93
ORTXORTXDelisted
ADR

ORCHARD THERAPEUTICS PLC

4.8M$76.2M4.4%

InflaRx N.V.

2.1M$75.8M4.4%$32.040.00%
1 qtr
New
83
2.7M$72.1M4.2%
1 qtr
New
83

MYOVANT SCIENCES LTD

3.7M$60.9M3.5%
1 qtr
New
83
EIDXEIDXDelisted

EIDOS THERAPEUTICS INC

2.2M$59.2M3.4%
1 qtr
New
83

CRINETICS PHARMACEUTICALS IN

1.9M$56.2M3.3%$30.510.00%
1 qtr
New
82

RHYTHM PHARMACEUTICALS INC

2M$52.4M3.1%$27.030.00%
1 qtr
New
82
IMMUIMMUDelisted

IMMUNOMEDICS INC

3M$43.1M2.5%
1 qtr
New
76

ARVINAS INC

3.1M$40.3M2.3%$13.160.00%
1 qtr
New
76
RARXRARXDelisted

RA PHARMACEUTICALS INC

4.9M$34M2.0%
1 qtr
New
67

TG Therapeutics, Inc.

8.2M$33.6M2.0%$3.980.00%
1 qtr
New
67
KALVKALVDelisted

KALVISTA PHARMACEUTICALS INC

1.4M$28.5M1.7%$19.560.00%
1 qtr
New
67
MNTAMNTADelisted

MOMENTA PHARMACEUTICALS INC

2.6M$28.2M1.6%
1 qtr
New
67
DRNADRNADelisted

DICERNA PHARMACEUTICALS INC

2.5M$26.3M1.5%
1 qtr
New
66
EIGREIGRDelisted

EIGER BIOPHARMACEUTICALS INC

2.4M$24.5M1.4%
1 qtr
New
66
$1.7B
AUM
25
Positions
Q4 2018
Filing
Rating · 3.0
Quarterly Portfolio Change
Not enough history yet
Activity profile
$ moved · Q4'18
New100%Increased0%Decreased0%Exited0%
Composition
Equity vs derivatives
Equity100%Puts0%Calls0%
Holding period
Avg <1 quarter
<1Q92%1-4Q0%1-2Y0%2Y+8%

RA CAPITAL MANAGEMENT, L.P. manages $1.7B across 25 positions as of Q4 2018. Top holdings: WVE (18.4%), ASND (15.5%), THOR (9.8%). Fund DNA: Balanced Allocator. HoldingsIntel Rating: 3/5.0.

Q4 2018 Summary

Active quarter - 25 new positions, 0 exits, 0 increased. Top move: WVE (NEW, conviction 97). Portfolio: $1.7B across 25 positions.

Top holdings by portfolio weight

Total AUM$2B
WVE18.38%
ASND15.46%
THOR9.84%
ZGNX5.06%
BCRX5.01%
ORTX4.44%
IFRX4.41%
SLDBN4.20%
MYOV3.55%
EIDX3.45%
Other3.27%

Portfolio allocation by GICS sector

Sectors2
Healthcare59.70%
Unknown40.30%

Behavioral investing profile

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Balanced Allocator- primarily Healthcare, Unknown
Compare DNA across all funds
7-dimension quality assessment
Solid(3.0 / 5.0)
Track Record65
Conviction42
Concentration91
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Similar Funds

Funds with similar investing DNA

Accumulation Streaks

Positions with 2+ consecutive quarters of increases - persistent directional conviction.

Security
2Q
SLDBSLDBSOLID BIOSCIENCES INC
Q1 2026 Q2 2026+6.2M shares+$87.5M
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Data sourced from SEC EDGAR 13F filings. Not financial advice. Full disclaimer

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